Dexter travels to the moon and finds that aliens are planning an invasion on Earth, and he uses his Robo-Dexo 2000 to stop them. It turns out that they only were interested in purchasing sweaters for the winter.
Monkey’s birthday party is interrupted by Barbequor (Robert Ridgely), an intergalactic villain who plans to eat the planets, and his sidekick, the Silver Spooner (Rob Paulsen).
After Dexter’s pencil rolls to the back of the school bus, Dexter goes to retrieve it, but legend says that no one has ever returned from the back of the bus.
Not interested in hearing Dee Dee’s long-winded story, Dexter gives her a silencing formula to keep her quiet, but it instead turns her into a giant monster still bent on telling her story. When he realizes that nothing can make her quiet, he becomes a giant monster himself.
Dexter is forced to take Dee Dee to the zoo. There, she ends up trying to save an ostrich with disastrous results. Dee Dee and the ostrich switches their places.
When Dexter is bitten by a clown’s dentures, he begins turning into a mad clown every night, terrorizing the town with his mayhem, and only Dee Dee, who knows mime, can stop him.
When an electrician comes to Dexter’s house to repair a blown-out fuse, he accidentally stumbles onto his laboratory, and Dexter enlists him to repair the lab.
Dexter’s family goes to the beach, where Dexter tries to communicate with whales. He must rescue Dee Dee (dressed as a mermaid), when she is captured by manic pirates.
Dexter and Mandark bring the Abraham Lincoln and George Washington faces respectively on Mount Rushmore to life and make them fight each other to determine who is the best.
Mandark disguises himself as Dexter’s mom to get into Dexter’s Lab. Unfortunately for Mandark, he now has to deal with Dexter, Dad, and Dee Dee’s requests, which are too much for him.
Dexter finds a lost Labrador Retriever, but when he teaches the dog to speak human language, he turns out to be very annoying, prompting Dexter to find the dog’s owner.
Dexter decides to work with Mandark, but finds himself doing all of the work. In the end, Mandark tries to press the button when Dexter connects the plug in the outlet to bring his show title back.