At a zoo, an artistic monkey paints Tom to look like a tiger after he accidentally wrecks his art during a chase against Jerry. As a result, Tom manages to scare Jerry as well as everyone else and every animal at the zoo with his tiger look.
At a laboratory, Jerry, using a virtual reality setup, plays a game in which Tom is hated by Mrs. Two-Shoes (while she likes Jerry) and is scared of Jerry. When Tom arrives at the laboratory, he plays a game in which Spike is scared of him (albeit still talking while Tom still does not).
Tom works at a zoo run by Spike, who orders him never to feed the zoo’s animals (only Spike can) or else he will have his badge. However, Jerry inadvertently and constantly causes trouble by framing Tom while he tries to prevent Jerry from feeding them.
A sequel to Pecos Pest (1955), Jerry’s uncle, Pecos Pest, returns to Tom and Jerry’s house for a visit, where he constantly sings and plays on his guitar, annoying and keeping both Tom and Jerry awake.
While listening to his favorite hip hop music, Jerry gets disrupted by the noise of the city, so he moves out of town to a farm owned by Tom. As a result, his music causes Tom’s pet hen to lay eggs quickly.
Spike and his girlfriend Toodles mistake Tom and Jerry for valets, as a result of which upon leaving their car to be parked while checking themselves in a hotel, Tom and Jerry unwillingly go on a wild and elaborate joyride across town.