Formerly poor, Tom and Jerry become rich overnight shortly after their numbers come in, so they split their millions and each set out to build a mansion across from each other.
Tom works at a zoo run by Spike, who orders him never to feed the zoo’s animals (only Spike can) or else he will have his badge. However, Jerry inadvertently and constantly causes trouble by framing Tom while he tries to prevent Jerry from feeding them.
A sequel to Pecos Pest (1955), Jerry’s uncle, Pecos Pest, returns to Tom and Jerry’s house for a visit, where he constantly sings and plays on his guitar, annoying and keeping both Tom and Jerry awake.
Tom is assigned to guard his owner’s garden of crops against pests, including Jerry and a clan of harvest mice who all resemble him (albeit with different-colored bandanas).
Tom seeks to catch and eat Jerry, the star of the show at a local ocean theme park along with a bald eagle, but he is then thwarted by another eagle, a seal and an octopus.