Mandark disguises himself as Dexter’s mom to get into Dexter’s Lab. Unfortunately for Mandark, he now has to deal with Dexter, Dad, and Dee Dee’s requests, which are too much for him.
With only one television in their apartment, Major Glory, Krunk, and Valhallen disagree on what to watch: Major Glory’s televised capture of the Disgruntled Postman, TV Puppet Pals, or the monster truck pull.
Dexter creates a new type of ink that lets him command people to do whatever he wants. However, when Mandark gets his hands on it, Dexter is the one that becomes commanded.
While out for dinner at a pizza restaurant, Dexter tries to slow down the “Whack the Weasel” machine to win a stuffed Monkey doll before Dee Dee does. Security captures him for tampering with the machine, and he falls into the hands of a mad scientist.
When Dee Dee tries to cut off a piece of her hair, she accidentally cuts off one of her pigtails. Dexter gives her a potion to make her missing hair grow back. However, Dee Dee squirts too much of it in her hair, and Dexter must return Dee Dee’s hair back to normal.
Dexter catches the chicken pox, and Dee Dee tells him a ridiculous tale that if he keeps scratching them, he will turn into an evil chicken. Dexter completely restrains himself so that he will not have to scratch it; unfortunately, he is unable to resist and his nonstop scratching eventually does just that.
Dee Dee dares Dexter into building her a giant robot similar to his Robo-Dexo 2000. They then team up to try to save an island’s population from being destroyed by an erupting volcano using their giant robots.
The U.S. army invades Dexter’s lab under the mistaken impression that aliens are using it as a base of operations on Earth, and Dexter must convince them that this is actually his lab, and also has to keep this a secret from Dee Dee.
Dexter travels to the moon and finds that aliens are planning an invasion on Earth, and he uses his Robo-Dexo 2000 to stop them. It turns out that they only were interested in purchasing sweaters for the winter.
Monkey must defend the city from a giant underground lava monster, Magmanamus (Brad Garrett), who cannot sleep because of the noise created by its residents.
Dexter and Dee Dee listen in on their parents’ conversation; they are playing Scrabble, but the way they talk makes it sound like Dad was cheating on Mom
Monkey encounters Simion (Maurice LaMarche), an intelligent anthropomorphic chimpanzee who seeks vengeance on humans for turning him into his current state.
