While developing a new gas for Kingpin to use as a weapon, a mistake triggers an explosion and Osborn disappears in the chaos. A new villain, the Green Goblin, appears and kidnaps all of Osborn’s enemies. Felicia later meets with Spider-Man, tells him that she is in love with him, and passionately kisses him.

The symbiote returns to Earth and travels to Ravencroft to reunite with Brock, who then escapes as Venom. He is ordered by Dormammu and Baron Mordo, to whom the symbiote owes its earthly return, to steal a machine from Stark Enterprises capable of releasing Dormammu from his own far-off dimension.

Angry over his son’s arrest and conviction, as well as Spider-Man now knowing his secret identity, to which he blames Alistair, Kingpin attempts to kill Spider-Man by turning Alistair into a cyborg to let him do it. Alistair’s father, Spencer, is revealed to have survived the explosion from the first season, but Kingpin has put […]

In a battle with Doctor Octopus, a medical research building is destroyed. Blaming himself, Peter is considering giving up being Spider-Man, when he meets an inter-dimensional being named Madame Web and his biggest fan, a little girl called Taina, who Spider-Man shares his origin story with. Doctor Octopus attacks with his new invention, the Octobot.

Norman Osborn returns as the Green Goblin where he and the Hobgoblin, whom he considers an imposter, clash over Ohn’s time dilation accelerator. Meanwhile, Felicia is engaged to a smug playboy of whom Peter is greatly suspicious of.

Spider-Man begins to worry about his growing mutation. In order to seek a cure, he heads to the Xavier mansion, where he encounters the X-Men. A brief fight occurs, after which Spider-Man explains his plight to Charles Xavier, who tells Spider-Man that he cannot cure him. Beast tells Spider-Man to go to Herbert Landon, who […]

Spider-Man is able to rescue Robbie and escape the explosion. The following day, Peter and Robbie visit Robbie’s friend Russian police officer Boris Pushkin who claims to have known Peter’s parents. Chief of Police Rhienholdt Kragov interrupts and threatens that Peter and Robbie will be arrested if they don’t leave. Boris gave Robbie Doctor Grotizick’s […]

Doctor Octopus attempts to blackmail Anastasia Hardy into paying him ransom money in order to fund his dangerous experiments, by threatening to reveal to the world that Felicia’s father was the crook known as “The Cat”.

Alistair, currently working as Silvermane’s top scientist, kidnaps the Black Cat. He then bribes Spider-Man into capturing either the Scorpion or the Vulture, whom both have unique DNA samples which are essential for Silvermane to restore his adulthood, in exchange for her release.

When Brock refuses to continue to work for Dormammu and Baron Mordo, they then turn the psychotic Cletus Kasady, into Carnage to collect life-force which is essential for Dormammu to enter Earth. Carnage kidnaps Dr. Ashley Kafka, whom Brock has fallen in love with. Brock then reluctantly teams with Iron Man and Spider-Man to save […]

Spider-Man walks into the trap of the supervillains, calling themselves the Insidious Six, at a warehouse. Spider-Man attempts to battle the six, but is captured and unmasked, although he manages to convince the supervillains that he is a fraud. Meanwhile, Dr. Connors reveals that Spider-Man has begun to mutate further, which is the cause of […]

After a brief fight with Mysterio, Peter learns that Mary Jane finally got her big break in recreating the film role made famous by actress Miranda Wilson. However, it was a trap set by Miranda, who had survived the accident on the filming of her movie; Mysterio had taken on his supervillain identity to gather […]

Spider-Man grieves over Mary Jane’s loss following his battle against the Green Goblin. Meanwhile, Tombstone, whilst incarcerated in Ryker’s Island, plots revenge on Robbie for previously causing his arrest. In exchange for assisting cell-mate Richard Fisk in a few brawls in prison, Richard requests that his father frame Robbie as a criminal mastermind.

Crawford has developed a cure for Spider-Man’s disease, but she is reluctant to give an untested serum to him that may result in permanent loss of his powers or worse. After an angry outburst from Spider-Man, she hands it over. At the ESU lab, Peter is secretly observed by Felicia’s latest love interest, Michael Morbius, […]

Trapped in the limbo between portals, the Green Goblin telepathically calls out to his son, Harry Osborn. Keeping his true identity a secret, he promises Harry that he will see his father soon if he becomes the second Green Goblin. Meanwhile, thinking Peter knows where Mary Jane is, Anna Watson unknowingly passes this information to […]

An ancient artifact known as the Tablet of Time has been uncovered. Kingpin wants to sell it, while elderly Silvermane wants to use it to restore his youth. Each crime lord kidnaps a useful hostage and a useless hostage.

Peter Parker / Spider-Man discovers that his science teacher, Dr. Curt Connors, has been turned into a deranged lizard due to an experiment gone wrong, and is abducting people throughout Manhattan.

Spider-Man seeks Dr. Connors’ aid to help reverse the aging effects of the Vulture’s talons. After absorbing Spider-Man’s youth and DNA, the Vulture mutates into the Man-Spider. Meanwhile, the Scorpion grabs Dr. Stillwell to seek a cure for his own mutation.

When Peter arrives for a date with Felicia Hardy, she is kidnapped by corrupt scientist Doctor Octopus, in order to force her mother to provide him with ransom money in which she promised to fund his experiments. Complicating things, Peter recognizes the madman as Otto Octavius, his favorite science mentor from his childhood days.

Peter, with his powers enhanced by his new suit, focuses his attention on Brock and Jameson and warns the latter to call off his reward, also mentioning Rhino and how Brock neglected to mention him. Jameson finds out from John that Brock was lying and fires him. He also calls off the manhunt for Spider-Man. […]

Dr. Jonathon Ohn is a brilliant scientist who created the time dilation accelerator portal-making machine for Tony Stark. However, following the battle against Venom and Carnage, Stark shut down the accelerator. Ohn is then approached by Kingpin, who funds Ohn’s research to have him continue the accelerator project, while Ohn falls in love with his […]

Astronauts John Jameson and Paul Stevens are sent to a newly discovered asteroid and discover a rock, known as “Promethium X”, which is said to be more powerful than plutonium. Unknown to them though, the “Promethium X” also contains a black, ooze-like creature, which manages to break free and tries to consume the two astronauts. […]

Spider-Man and Blade put aside their differences in an attempt to prevent Morbius from using the Neogenic Recombinator to transform everyone into vampires like himself. They team up with Lt. Lee, who falls for Blade. During one attempt to stop Morbius, he kidnaps Peter’s aunt May and Felicia, causing Spider-Man and Blade to have a […]

Mac Gargan, a small-time crook hired by Jameson to follow Peter and find out how he is able to get pictures of Spider-Man, strikes a deal with Jameson to eliminate Spider-Man. Gargan is taken to the lab of Dr. Farley Stillwell, where he is transformed into the supervillain Scorpion.