Monkey must defend the city from a giant underground lava monster, Magmanamus (Brad Garrett), who cannot sleep because of the noise created by its residents.
When his family is suffering from the flu, Dexter tries his best to not acquire the illness, but his efforts are thwarted by a sick Dee Dee’s presence in his lab.
When Dexter is bitten by a clown’s dentures, he begins turning into a mad clown every night, terrorizing the town with his mayhem, and only Dee Dee, who knows mime, can stop him.
Dexter reluctantly takes piano lessons from Professor Williams (Paul Williams), but when the Professor stumbles onto Dexter’s lab, he discovers that Dexter has more musical talent than he thought.
During a trip to Japan as part of a student exchange program, Dexter accidentally releases a giant monster with an axe-like head from a volcano, forcing him to enlist the aid of his family to defeat it.
Since his studying is interrupting his favorite TV shows, Dexter creates a helmet to absorb the shows directly. However, the plan backfires when he randomly snaps into television-based outrages.