Stranded in the Negative Zone, the Avengers must join forces with their enemies – including former members of the Masters of Evil – to fight off an army of strange insectoid creatures that are laying siege to 42.
Kang the Conqueror revisits a time where Captain America and Bucky took down a HYDRA portal to Asgard as Kang believes Captain America is responsible for destroying Kang’s timeline.
The Leader has placed an expanding dome of pure gamma radiation around the Cube, with anyone caught inside it being mutated into a Gamma Monster. The Avengers, along with the support of S.H.I.E.L.D., enter the Cube in an attempt to the destroy the Gamma Generator.
Ant Man and Wasp take down Klaw and Whirlwind. Afterwards Klaw helps M’Baku (a.k.a. the Man Ape) take down T’Chaka and become king of Wakanda. But T’Challa dons the Black Panther suit and flees to look for help.
A mysterious explosion seemingly kills Hank Pym in his college laboratory, but as the Avengers and their friends mourn the loss of their fallen comrade-in-arms, a fearless new vigilante calling himself Yellowjacket – endowed with the same powers and technology as Ant-Man/Giant-Man and Wasp – begins taking out the members of the Serpent Society.
The Enchantress seeks revenge on Baron Zemo and the Masters of Evil for betraying her, and the remaining supervillains go to the Avengers for protection.
With Thor and Hawkeye in tow, Captain America travels to Wakanda to have his shield repaired and to persuade Black Panther to rejoin the team. But a mysterious figure known only as the Vision arrives to steal the shield – along with Wakanda’s supply of vibranium.
With the Avengers, minus Ant-Man, turned into Gamma Monsters, Hawkeye must convince the Hulk to help fight the Leader and the Abomination while Thor (who was unaffected by the Gamma Dome) fights the Absorbing Man.
The Vision awakens after a month of repairs to find that Tony Stark and his fellow Avengers have taken over the world. With the whole planet turned against him, the Vision must get to the bottom of Stark’s “utopia” – only to discover an unlikely figure to be the true power behind the Avengers’ throne.
When the Hulk’s name is cleared of the crimes committed by the Red Hulk, the Avengers find that the deception put forth by Captain America’s Skrull doppelganger has made the green-skinned juggernaut even more of a loose cannon than before.
Captain America ponders the mystery of the Winter Soldier and enlists Nick Fury’s aid to find him when the Red Skull escapes from prison and massive robots – the Sleepers – arise as part of a contingency plan by the founder of HYDRA to destroy Washington, D.C.
Captain America teams up with the equally mistrusted Spider-Man to fight the Serpent Society when they try to rescue Viper and King Cobra from S.H.I.E.L.D. custody.
Nick Fury returns, having assembled a team of heroes in secret (himself, Black Widow, Mockingbird, and Quake) to gather information about the impending Skrull invasion of Earth.