A sequel to Pecos Pest (1955), Jerry’s uncle, Pecos Pest, returns to Tom and Jerry’s house for a visit, where he constantly sings and plays on his guitar, annoying and keeping both Tom and Jerry awake.
At a laboratory, Jerry, using a virtual reality setup, plays a game in which Tom is hated by Mrs. Two-Shoes (while she likes Jerry) and is scared of Jerry. When Tom arrives at the laboratory, he plays a game in which Spike is scared of him (albeit still talking while Tom still does not).
Tom works at a zoo run by Spike, who orders him never to feed the zoo’s animals (only Spike can) or else he will have his badge. However, Jerry inadvertently and constantly causes trouble by framing Tom while he tries to prevent Jerry from feeding them.
Tom seeks to catch and eat Jerry, the star of the show at a local ocean theme park along with a bald eagle, but he is then thwarted by another eagle, a seal and an octopus.
When he tries out a new cheese-in-a-can that Rick and Ginger buy, Tom has a crazy day when he experiences hallucinations based on the show’s other scenarios.
Dr. Bigby creates cookies that give super strength and Jerry and Napoleon eat them and they have fun terrorizing Tom. He eventually gets revenge on them, however.
Toodles hires detectives Tom and Jerry to investigate and protect her against a threat to her Tuna can inheritance. They go investigate, and a mysterious and menacing figure keeps trying to hurt them.
When Jerry and Tuffy are planning to go on a vacation, Jerry gets mailed away when Tuffy forgets to bring a camera along with them, so Tuffy stays home and outwits Tom while Jerry attempts to come back home.
Upon seeing Tom unable to catch Jerry, Butch recruits the former to join the League of Cats, a secret organization of cats who work together to catch mice.
When a burglar has been breaking in homes, Rick and Ginger leave Spike in charge and Spike teaches Tom and Jerry how to protect their home and defend themselves.
