When Hildie and Beatie leaves their home, Tom and Jerry comes across Little Quacker who turns into a big monster on and off when he eats the stew that Tom made standing on the window.

Jerry and his friend Napoleon are lab mice and Tom is outside going through trash until he sees the two mice that he wants for an appetite and things go crazy when Dr. Bigby’s elderly cat becomes a vicious kitten and chases the mice.

Rick takes Tom and Spike to the vet for their checkup while Ginger hires an exterminator to get rid of Jerry and Tuffy.

Tom throws Spike’s beloved chew toy over the fence and has to get it back when he sees how heartbroken Spike becomes.

Tom gets Spike sent to obedience school for being naughty, and Jerry is left without a protector. When Spike returns, Tom tries hard to get Spike to revert to his old ways. Jerry fights back to make sure that Spike keeps his cool.

With eight of his nine lives gone, Tom uses magic in order to bring them back.

Rick and Ginger go on a road trip to visit Ginger’s great aunt Claire, but on the trip, Spike and Tom get lost, and Spike deals with “The Doggie of Doom” who follows them.

One of Dr. Bigby’s inventions makes things float, so Jerry and Napoleon try it on themselves and then they try it out on Tom.

An asteroid is heading towards earth and Tom and Jerry are determined to stop it; Napoleon is hungry for vending machine food.

Dr. Bigby invents a transporting machine that transports Tom and Jerry to Paris where they meet a girl mouse and a girl cat.

Tom and Jerry are locked out in the snow.

Ginger gets a high-tech mattress and Tom is forbidden to sleep on it, but when Butch sees it and tries it out, it results in him, Tom, and Jerry fighting over the bed.