Jerry and his friend Napoleon are lab mice and Tom is outside going through trash until he sees the two mice that he wants for an appetite and things go crazy when Dr. Bigby’s elderly cat becomes a vicious kitten and chases the mice.

When Ginger and Rick leave the house for a trip, Tom and Jerry plan to serve their girlfriends dinner, but things get competitive with them.

Rick and Ginger’s vacation continues on a cruise ship, where to make sure Tom and Spike don’t cause havoc, they keep them in the carriers. Jerry and Tuffy invade their vacation again, and Meathead, the ship’s cat, hunts down Jerry and Tuffy on the ship.

With eight of his nine lives gone, Tom uses magic in order to bring them back.

An asteroid is heading towards earth and Tom and Jerry are determined to stop it; Napoleon is hungry for vending machine food.

When Jerry and Tuffy are planning to go on a vacation, Jerry gets mailed away when Tuffy forgets to bring a camera along with them, so Tuffy stays home and outwits Tom while Jerry attempts to come back home.

Jerry tricks Tom by pretending he has turned into a vampire mouse.

When Ginger’s wedding ring falls down the drain, Tom, Jerry and Spike have to get it back before she finds out.

When an injured Tom sees a female cat named Misty across the street get catnapped, him and Jerry seeks help from her dog friend, Scarf to locate her.

The witch sisters both commemorate the passing of their mother and Tom tries to help out by bringing her back from the grave.