Jerry and his friend Napoleon are lab mice and Tom is outside going through trash until he sees the two mice that he wants for an appetite and things go crazy when Dr. Bigby’s elderly cat becomes a vicious kitten and chases the mice.
After accidentally trashing a fancy hotel lobby during another chase against Jerry, Tom is hired as a bellboy by the hotel’s manager in order to pay for the damages. Unfortunately, Jerry makes Tom’s assignments difficult.
Both Tom and Butch compete against to go after Ginger’s mom’s bird when her and Rick watch it for the weekend. Jerry also makes sure nothing happens to the bird.
When Hildie and Beatie leaves their home, Tom and Jerry comes across Little Quacker who turns into a big monster on and off when he eats the stew that Tom made standing on the window.
Tom gets Spike sent to obedience school for being naughty, and Jerry is left without a protector. When Spike returns, Tom tries hard to get Spike to revert to his old ways. Jerry fights back to make sure that Spike keeps his cool.
Tom seeks to catch and eat Jerry, the star of the show at a local ocean theme park along with a bald eagle, but he is then thwarted by another eagle, a seal and an octopus.
When he tries out a new cheese-in-a-can that Rick and Ginger buy, Tom has a crazy day when he experiences hallucinations based on the show’s other scenarios.
