When Dexter’s friends become tired of his complicated traps and cheating while playing a role-playing game, they put Dee Dee in his place. She changes the style of play, which annoys Dexter but impresses his friends.
Dexter’s father sleepwalks into Dexter’s lab. Dexter discovers this, and now has to escort him out of the lab without waking him up, which proves more difficult than thought.
Dexter reluctantly takes piano lessons from Professor Williams (Paul Williams), but when the Professor stumbles onto Dexter’s lab, he discovers that Dexter has more musical talent than he thought.
Dee Dee’s stuffed animals come to life and roam the house when Dee Dee uses a formula that brings inanimate objects to life, which delights Dee Dee, much to his dismay.
On his birthday, Dexter makes himself invisible so that he can find out whether his parents have bought him the Major Glory action figure he always wanted.
Dexter is forced to take Dee Dee to the zoo. There, she ends up trying to save an ostrich with disastrous results. Dee Dee and the ostrich switches their places.
Dexter catches the chicken pox, and Dee Dee tells him a ridiculous tale that if he keeps scratching them, he will turn into an evil chicken. Dexter completely restrains himself so that he will not have to scratch it; unfortunately, he is unable to resist and his nonstop scratching eventually does just that.
When his mother falls ill, Dexter creates a robot to do her chores. Dee Dee gets hold of its remote control and wreaks havoc, forcing Dexter to create a second robot to counter Dee Dee’s.
To fix their apartment’s plumbing, Krunk and Valhallen go to the basement, where they meet Ratman (Maurice LaMarche), a diminutive vigilante raised by rats (a parody of Batman).
Dee Dee and her friends, Lee Lee and Mee Mee, enter Dexter’s lab and wreak havoc. Dexter clones himself to stop them, but the girls too make clones of themselves.
Dexter is disappointed when he ends up at an Amish farm instead of a high-tech farm for summer camp. His attempts to modernize the Amish family do not go well.
Dexter, Monkey, Agent Honeydew, the Justice Friends, Dee Dee, her imaginary friend Koosalagoopagoop, Mandark, his parents, and Dexter’s parents participate in a cross-country race a la Wacky Races.
To learn more about girls, Dexter camouflages himself and enters Dee Dee’s room, where she is having a sleepover with her friends Lee Lee and Mee Mee. He gets caught by the girls, who force him to take part in their activities.
In need of an assistant to operate his latest invention, Dexter performs a brain transplant on Dee Dee to make her smart enough to fulfill the role. With her new brain, Dee Dee proves to be more intelligent than Dexter.
