When Dexter’s nightmares become frequent and problematic, he invents a machine that allows him to have nice dreams, as long as Dee Dee can operate it properly while she is awake.
Dexter’s school and parents decide to send him to college. He ignores his fellow students, who prefer to “party now, study later”, until his mind finally snaps from the workload.
Mandark brings his lab duck Ducky for show and tell to counter Dexter and his lab monkey. Though neither creature displays remarkable characteristics at school, Ducky, unbeknownst to Mandark, is the alter ego of supervillain Quackor the Fowl.
Dee Dee’s stuffed animals come to life and roam the house when Dee Dee uses a formula that brings inanimate objects to life, which delights Dee Dee, much to his dismay.
Dee Dee accidentally shuts down Dexter’s lab, and he has to power it back. In the process, Dee Dee attempts to keep Dexter from finding out what she really did.
Dexter has a crush on his teenage babysitter Lisa (Kath Soucie). When he finds out that she has a boyfriend, he sabotages their relationship and accelerates his age by ten years in an attempt to win her heart.
Dee Dee and her friends, Lee Lee and Mee Mee, enter Dexter’s lab and wreak havoc. Dexter clones himself to stop them, but the girls too make clones of themselves.
Dexter finds a lost Labrador Retriever, but when he teaches the dog to speak human language, he turns out to be very annoying, prompting Dexter to find the dog’s owner.
Dexter is forced to take Dee Dee to the zoo. There, she ends up trying to save an ostrich with disastrous results. Dee Dee and the ostrich switches their places.
Dexter reluctantly takes piano lessons from Professor Williams (Paul Williams), but when the Professor stumbles onto Dexter’s lab, he discovers that Dexter has more musical talent than he thought.
During a trip to Japan as part of a student exchange program, Dexter accidentally releases a giant monster with an axe-like head from a volcano, forcing him to enlist the aid of his family to defeat it.
Dexter and Dee Dee listen in on their parents’ conversation; they are playing Scrabble, but the way they talk makes it sound like Dad was cheating on Mom