Dexter reluctantly takes piano lessons from Professor Williams (Paul Williams), but when the Professor stumbles onto Dexter’s lab, he discovers that Dexter has more musical talent than he thought.
Dexter’s family goes to the beach, where Dexter tries to communicate with whales. He must rescue Dee Dee (dressed as a mermaid), when she is captured by manic pirates.
Dexter and Dee Dee listen in on their parents’ conversation; they are playing Scrabble, but the way they talk makes it sound like Dad was cheating on Mom
After a crime prevention talk at school, Dee Dee, Lee Lee, and Mee Mee become crime fighters, but they unintentionally end up being neighborhood criminals.
When Dexter is asked to bring his mother to school, he disguises Dee Dee as her so that she can take her place, but Dee Dee does not behave like their mother.
When Dexter tries to inject himself into an ill Dee Dee to find a cure to the common cold, he accidentally ends up inside his dog, believing that Dee Dee is infected with a dog virus.
Dexter’s lab is threatened with repossession unless he can repay his debt to NASA. When Dee Dee wins the same amount in a lottery, he decides to steal her money out of desperation.
Monkey encounters Simion (Maurice LaMarche), an intelligent anthropomorphic chimpanzee who seeks vengeance on humans for turning him into his current state.
Dexter, Monkey, Agent Honeydew, the Justice Friends, Dee Dee, her imaginary friend Koosalagoopagoop, Mandark, his parents, and Dexter’s parents participate in a cross-country race a la Wacky Races.
After Dexter orders and eats a giant burrito, he suffers severe stomach pains. Believing a test the computer gave him, he assumes that he has only 30 minutes to live.