Dexter’s lab is threatened with repossession unless he can repay his debt to NASA. When Dee Dee wins the same amount in a lottery, he decides to steal her money out of desperation.
In a parody of Tom and Jerry, Dexter accidentally switches his brain with that of a mouse’s and must avoid his mother when she decides to exterminate him.
In need of an assistant to operate his latest invention, Dexter performs a brain transplant on Dee Dee to make her smart enough to fulfill the role. With her new brain, Dee Dee proves to be more intelligent than Dexter.
After Dexter orders and eats a giant burrito, he suffers severe stomach pains. Believing a test the computer gave him, he assumes that he has only 30 minutes to live.
Mandark gets inside Dexter’s computer system and creates a computer virus, so Dexter must follow him inside and kick him out from cyberspace. However, Dee Dee has other plans in mind.
Dad decides to give the car a retouch, but keeps breaking things and saying he will fix it later. After having enough, he pushes the car over a cliff, and below it are other crushed cars, meaning this was not the first time.
When Dexter is asked to bring his mother to school, he disguises Dee Dee as her so that she can take her place, but Dee Dee does not behave like their mother.
Mandark brings his lab duck Ducky for show and tell to counter Dexter and his lab monkey. Though neither creature displays remarkable characteristics at school, Ducky, unbeknownst to Mandark, is the alter ego of supervillain Quackor the Fowl.
Since his studying is interrupting his favorite TV shows, Dexter creates a helmet to absorb the shows directly. However, the plan backfires when he randomly snaps into television-based outrages.
Dexter and Koos must save Peepers to keep the land of Kooz from disappearing. However, they must contend with a villain who is determined to make the land of Kooz disappear forever.