A mysterious explosion seemingly kills Hank Pym in his college laboratory, but as the Avengers and their friends mourn the loss of their fallen comrade-in-arms, a fearless new vigilante calling himself Yellowjacket – endowed with the same powers and technology as Ant-Man/Giant-Man and Wasp – begins taking out the members of the Serpent Society.
Stranded in the Negative Zone, the Avengers must join forces with their enemies – including former members of the Masters of Evil – to fight off an army of strange insectoid creatures that are laying siege to 42.
The Avengers are ambushed and captured, one by one, by Ultron’s team of synthezoid Avengers as part of the wayward android’s plan to rid the world of “flawed” humans, perfect himself, and construct a mate.