In need of an assistant to operate his latest invention, Dexter performs a brain transplant on Dee Dee to make her smart enough to fulfill the role. With her new brain, Dee Dee proves to be more intelligent than Dexter.
On his birthday, Dexter makes himself invisible so that he can find out whether his parents have bought him the Major Glory action figure he always wanted.
The U.S. army invades Dexter’s lab under the mistaken impression that aliens are using it as a base of operations on Earth, and Dexter must convince them that this is actually his lab, and also has to keep this a secret from Dee Dee.
Dee Dee gets a song stuck in her head, which is actually a virus. Dexter and Mom soon catch it, and Dexter has to reverse the effects of this. He succeeds at the end, not knowing that Dad also caught it.
Dexter’s father is challenged to an arm wrestling match by a man named Earl at a truck stop. Stunned at the strength of Earl and his determination to beat his father, Dexter attaches a robotic arm to his father to enable him to win.
During a trip to Japan as part of a student exchange program, Dexter accidentally releases a giant monster with an axe-like head from a volcano, forcing him to enlist the aid of his family to defeat it.
When his television show is interrupted by the Emergency Broadcast System, Dexter sets about fixing any emergencies in the neighborhood to make the signal go away.
When Dexter’s nightmares become frequent and problematic, he invents a machine that allows him to have nice dreams, as long as Dee Dee can operate it properly while she is awake.
Mandark disguises himself as Dexter’s mom to get into Dexter’s Lab. Unfortunately for Mandark, he now has to deal with Dexter, Dad, and Dee Dee’s requests, which are too much for him.
Created and narrated by a six-and-a-half-year-old boy named Tyler Samuel Lee, who sent a tape containing the episode’s audio to Cartoon Network,[9] the story follows Dexter and Mandark’s robot “brother” Computress teaming up to make Mandark’s head shrink.