After the plane incident, Rick and Ginger sneak Tom and Spike at “Paradise Resort” where pets are not allowed, but when Rick and Ginger leave Tom and Spike in their room, Jerry and Tuffy cause them trouble.
An unlucky dog named Dutch goes to Detectives Tom and Jerry, saying that a ruby stone he has been guarding from his great grandfather’s master pirate “Captain Wrongway Weston” is taken from a female dog named Roxy, who is also unlucky.
When Tom ruins Hildie and Beatie’s potions, they get fed up with him and he overhears them wanting a black cat instead of him. He makes and drinks a potion that turns him into a black cat, and they assume he’s another cat.
When Hildie gets a magic mirror that predicts the future, Tom sees predictions of himself being fed a fish, which is good, and then a bad prediction: switching heads with Beatie.
Dr. Bigby creates cookies that give super strength and Jerry and Napoleon eat them and they have fun terrorizing Tom. He eventually gets revenge on them, however.
When a burglar has been breaking in homes, Rick and Ginger leave Spike in charge and Spike teaches Tom and Jerry how to protect their home and defend themselves.
Nancy, Tom’s owner from Baby Puss (1943), brings Tom to her elementary school for show-and-tell in which she wants Tom to win the gold star for best pet.
When Hildie and Beatie leaves their home, Tom and Jerry comes across Little Quacker who turns into a big monster on and off when he eats the stew that Tom made standing on the window.
Tom seeks to catch and eat Jerry, the star of the show at a local ocean theme park along with a bald eagle, but he is then thwarted by another eagle, a seal and an octopus.
Ginger and Rick decide to bring Tom and Spike along on their Hawaiian vacation, but on their plane flight, Jerry and Tuffy tag along as well. Tom and Spike get loose out of their cages, and before long, things go awry.
Formerly poor, Tom and Jerry become rich overnight shortly after their numbers come in, so they split their millions and each set out to build a mansion across from each other.
Tom and Jerry are sent out to go retrieve an ingredient for the witch sisters by sundown before they are turned into frogs, but Tom develops a crush on Princess Toodles. Butch does, too, so they compete against each other in games to win her love while Jerry tries desperately to retrieve the ingredient himself.
