Detectives Tom and Jerry discover Butch and a squirrel are stealing their business and later discover they are con artists and are stealing from customers.

Detectives Tom and Jerry are hired by Polly the Dog to get back her collar from mean Barkley at the park. After a series of incidents involving the pound “jail” and an electric fence, Barkley reforms when he meets Polly and falls in love with her.

Spike develops allergies and Rick thinks that Spike is likely allergic to Tom, so Rick gets a hypoallergenic kitten named Glory for Ginger; Spike, Tom and Jerry plan to get rid of the nice kitten who is actually anything but and will do whatever it takes to be an only pet.

When a burglar has been breaking in homes, Rick and Ginger leave Spike in charge and Spike teaches Tom and Jerry how to protect their home and defend themselves.

Tom gets Spike sent to obedience school for being naughty, and Jerry is left without a protector. When Spike returns, Tom tries hard to get Spike to revert to his old ways. Jerry fights back to make sure that Spike keeps his cool.