A sequel to Pecos Pest (1955), Jerry’s uncle, Pecos Pest, returns to Tom and Jerry’s house for a visit, where he constantly sings and plays on his guitar, annoying and keeping both Tom and Jerry awake.
Upon seeing Tom unable to catch Jerry, Butch recruits the former to join the League of Cats, a secret organization of cats who work together to catch mice.
Spike develops allergies and Rick thinks that Spike is likely allergic to Tom, so Rick gets a hypoallergenic kitten named Glory for Ginger; Spike, Tom and Jerry plan to get rid of the nice kitten who is actually anything but and will do whatever it takes to be an only pet.
Spike and his girlfriend Toodles mistake Tom and Jerry for valets, as a result of which upon leaving their car to be parked while checking themselves in a hotel, Tom and Jerry unwillingly go on a wild and elaborate joyride across town.