When Hildie and Beatie go away on a vacation, Tom and Jerry has problems when their ghost nephew, Grayson, comes over and throws a large party with his friends and takes their crystal ball for bowling.
At a zoo, an artistic monkey paints Tom to look like a tiger after he accidentally wrecks his art during a chase against Jerry. As a result, Tom manages to scare Jerry as well as everyone else and every animal at the zoo with his tiger look.
Upon seeing Tom unable to catch Jerry, Butch recruits the former to join the League of Cats, a secret organization of cats who work together to catch mice.
When Jerry and Tuffy are planning to go on a vacation, Jerry gets mailed away when Tuffy forgets to bring a camera along with them, so Tuffy stays home and outwits Tom while Jerry attempts to come back home.
A sequel to Pecos Pest (1955), Jerry’s uncle, Pecos Pest, returns to Tom and Jerry’s house for a visit, where he constantly sings and plays on his guitar, annoying and keeping both Tom and Jerry awake.
