Detectives Tom and Jerry are hired by Polly the Dog to get back her collar from mean Barkley at the park. After a series of incidents involving the pound “jail” and an electric fence, Barkley reforms when he meets Polly and falls in love with her.
After accidentally trashing a fancy hotel lobby during another chase against Jerry, Tom is hired as a bellboy by the hotel’s manager in order to pay for the damages. Unfortunately, Jerry makes Tom’s assignments difficult.
Tom is assigned to guard his owner’s garden of crops against pests, including Jerry and a clan of harvest mice who all resemble him (albeit with different-colored bandanas).
Toodles hires detectives Tom and Jerry to investigate and protect her against a threat to her Tuna can inheritance. They go investigate, and a mysterious and menacing figure keeps trying to hurt them.
Detectives Tom and Jerry discover Butch and a squirrel are stealing their business and later discover they are con artists and are stealing from customers.
When Hildie and Beatie go away on a vacation, Tom and Jerry has problems when their ghost nephew, Grayson, comes over and throws a large party with his friends and takes their crystal ball for bowling.