Dexter finds the exact opposite of his family, a hyperactive boy who is like Dee Dee and has scientist parents who are like Dexter. Sensing to fit in, he switches places with the boy.
Mandark Astronomanov, a new student at Dexter’s school, seems to be superior to Dexter academically. Mandark forces Dexter to shut down his lab so that Mandark’s lab can gain more power. However, with the help of Dee Dee, Dexter manages to destroy Mandark’s lab.
Monkey must defend the city from a giant underground lava monster, Magmanamus (Brad Garrett), who cannot sleep because of the noise created by its residents.
Dee Dee accidentally shuts down Dexter’s lab, and he has to power it back. In the process, Dee Dee attempts to keep Dexter from finding out what she really did.
When Dexter is bitten by a clown’s dentures, he begins turning into a mad clown every night, terrorizing the town with his mayhem, and only Dee Dee, who knows mime, can stop him.
After a crime prevention talk at school, Dee Dee, Lee Lee, and Mee Mee become crime fighters, but they unintentionally end up being neighborhood criminals.
Dexter and Dee Dee’s father buys a video game for them to play, but the game sucks Dexter inside when he plugs in the cartridge, and it is up to Dee Dee to bring him out.