Dexter and Mandark bring the Abraham Lincoln and George Washington faces respectively on Mount Rushmore to life and make them fight each other to determine who is the best.
To learn more about girls, Dexter camouflages himself and enters Dee Dee’s room, where she is having a sleepover with her friends Lee Lee and Mee Mee. He gets caught by the girls, who force him to take part in their activities.
Dexter’s family goes to the beach, where Dexter tries to communicate with whales. He must rescue Dee Dee (dressed as a mermaid), when she is captured by manic pirates.
After Dee Dee declares that she can beat Dexter in any game, Dexter challenges her to a series of games in his lab, though he prefers to win by cheating.
Dee Dee’s stuffed animals come to life and roam the house when Dee Dee uses a formula that brings inanimate objects to life, which delights Dee Dee, much to his dismay.
After a crime prevention talk at school, Dee Dee, Lee Lee, and Mee Mee become crime fighters, but they unintentionally end up being neighborhood criminals.
The U.S. army invades Dexter’s lab under the mistaken impression that aliens are using it as a base of operations on Earth, and Dexter must convince them that this is actually his lab, and also has to keep this a secret from Dee Dee.
In need of an assistant to operate his latest invention, Dexter performs a brain transplant on Dee Dee to make her smart enough to fulfill the role. With her new brain, Dee Dee proves to be more intelligent than Dexter.