Dexter finds a lost Labrador Retriever, but when he teaches the dog to speak human language, he turns out to be very annoying, prompting Dexter to find the dog’s owner.
In a parody of Tom and Jerry, Dexter accidentally switches his brain with that of a mouse’s and must avoid his mother when she decides to exterminate him.
Dexter’s new device allows him to study for the next day’s French test while sleeping. It malfunctions, causing a single phrase (omelette du fromage) to repeat throughout the night, causing Dexter to wake up the next morning speaking nothing else except omelette du fromage.
After fellow Justice Friend White Tiger helps Valhallen stop a super-villain, the latter invites him to spend the night in his apartment, forgetting that Major Glory is allergic to cats.
In need of an assistant to operate his latest invention, Dexter performs a brain transplant on Dee Dee to make her smart enough to fulfill the role. With her new brain, Dee Dee proves to be more intelligent than Dexter.
Dee Dee’s stuffed animals come to life and roam the house when Dee Dee uses a formula that brings inanimate objects to life, which delights Dee Dee, much to his dismay.
Since his studying is interrupting his favorite TV shows, Dexter creates a helmet to absorb the shows directly. However, the plan backfires when he randomly snaps into television-based outrages.
Mandark brings his lab duck Ducky for show and tell to counter Dexter and his lab monkey. Though neither creature displays remarkable characteristics at school, Ducky, unbeknownst to Mandark, is the alter ego of supervillain Quackor the Fowl.
After a crime prevention talk at school, Dee Dee, Lee Lee, and Mee Mee become crime fighters, but they unintentionally end up being neighborhood criminals.
When Dexter is bitten by a clown’s dentures, he begins turning into a mad clown every night, terrorizing the town with his mayhem, and only Dee Dee, who knows mime, can stop him.
Dexter’s family goes to the beach, where Dexter tries to communicate with whales. He must rescue Dee Dee (dressed as a mermaid), when she is captured by manic pirates.
To prevent himself from being taken away by aliens for experimentation, Dexter tricks Dee Dee into going instead, but he regrets his decision after realizing how much he cares for her.