Dexter falls victim to one of his own inventions and sends Dee Dee back in time to warn his past self about the consequences, but the past Dexter proves hard to convince.
Dexter’s father is challenged to an arm wrestling match by a man named Earl at a truck stop. Stunned at the strength of Earl and his determination to beat his father, Dexter attaches a robotic arm to his father to enable him to win.
Dexter’s lab is threatened with repossession unless he can repay his debt to NASA. When Dee Dee wins the same amount in a lottery, he decides to steal her money out of desperation.
Mandark disguises himself as Dexter’s mom to get into Dexter’s Lab. Unfortunately for Mandark, he now has to deal with Dexter, Dad, and Dee Dee’s requests, which are too much for him.
Dexter travels to the moon and finds that aliens are planning an invasion on Earth, and he uses his Robo-Dexo 2000 to stop them. It turns out that they only were interested in purchasing sweaters for the winter.
In need of an assistant to operate his latest invention, Dexter performs a brain transplant on Dee Dee to make her smart enough to fulfill the role. With her new brain, Dee Dee proves to be more intelligent than Dexter.
The U.S. army invades Dexter’s lab under the mistaken impression that aliens are using it as a base of operations on Earth, and Dexter must convince them that this is actually his lab, and also has to keep this a secret from Dee Dee.
Dexter reluctantly takes piano lessons from Professor Williams (Paul Williams), but when the Professor stumbles onto Dexter’s lab, he discovers that Dexter has more musical talent than he thought.